Am I Eligible?
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About the Trial
Medical researchers are conducting The Content clinical research trial to determine the safety and effectiveness of an investigational drug for urine leakage in patients with Multiple Sclerosis (MS) or who have a spinal cord injury.
There’s never a good time for urine leakage. Living with urine leakage can impact your personal, professional and social life. But, there may be another option. This investigational drug may help reduce or even stop urine leakage.
About the Trial
Some people have a neurological condition such as a spinal cord injury or multiple sclerosis (MS) that affects communication between the spinal cord and bladder.
This condition is called Neurogenic Detrusor Overactivity (NDO), and causes the bladder muscle to contract too often, leading to frequent, involuntary leakage of urine (incontinence).
Many people experiencing urine leakage are not satisfied with their current treatments. The Content clinical research trial is currently evaluating an investigational drug for its effectiveness on urine leakage in patients with MS or who have a spinal cord injury.
Participation in the Content clinical research trial may last up to approximately 2 years and includes clinic visits and periodic telephone calls. During the trial, you will be required to keep a bladder diary. At some of your trial visits, you may also have the following assessments: physical exam, vital signs, blood or urine tests, and urodynamics.
If you qualify to participate, you will be randomly assigned to receive either the investigational drug or a placebo. The placebo has no active drug in it. Neither you nor the person administering the drug will know if you are receiving the active drug or the placebo. Patients who request and receive a retreatment in the trial will receive the active investigational drug (not placebo). Patients can receive retreatment as early as 12 weeks after the first dose if required.
The investigational drug is administered by injection. You may receive anesthesia and sedation to help you be more comfortable.